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Dr Lungile Sitole

Director: Soweto Science Centre and Senior Lecturer
Name: Lungil Sitole
Location: C2 Lab 406 Auckland Park Kingsway Campus
Academic Development Centre Staff, Biochemistry Staff  Staff Members

Contact Details:
Tel: +27 (0) 11 559 2984

Email: lsitole@uj.ac.za

About Dr Lungile Sitole

Dr Lungile’s research focus is on the application of metabonomics as a tool to better characterize infectious diseases such as HIV/AIDS and HIV-associated comorbidities and the elucidation of treatment response mechanisms. In addition, the group focuses on the synthesis of metal complexes as anti-HIV and anti-Cancer agents.

LINKS:

Google scholar: https://scholar.google.co.za/citations?user=TT–6G8AAAAJ&hl=en

ORCID: https://orcid.org/0000-0003-0739-9504

Recent Publications:

  1. Moyo, B., Mhlongo, M., Sitole, L. (2024). Cytotoxic activity of Ocimum tenuiflorum crude extracts against an A375 malignant melanoma cell line. South African Journal of Botany, 175, 514-522.

  1. Hussan, A., Moyo, B., Amenuvor, G., Meyer, D., Sitole, L. (2023). Investigating the antitumor effects of a novel ruthenium (II) complex on malignant melanoma cells: An NMR-based metabolomic approach. Biochemical and Biophysical Research Communications, 686, 149169.

 

  1. Sitole, L., Fortuin, R., Tugizimana, F. (2022). Metabolic profiling of HIV infected individuals on an AZT-based antiretroviral treatment regimen reveals persistent oxidative stress. Journal of Pharmaceutical and Biomedical Analysis, Volume 220, 2022, 114986.

  1. Ncube, E.N., Sitole, L., Steenkamp, P.A., Steenkamp, L.H., Dubery, I.A. (2022). Untargeted Metabolomics Exploration of the Growth Stage-Dependent Chemical Space of the Sclareol-Converting Biocatalyst Hyphozyma roseonigra. Catalysts, 12(10):1225.

  1. Baloyi, N.N., Tugizimana, F., Sitole L. (2022). Metabolomics assessment of vitamin D impact in Pam3CSK4 stimulation. Omics,18, 397-407.

  1. Gabazana, Z., Sitole, L. (2021). Raman-based metabonomics unravels metabolic changes related to a first line tenofovir-based treatment in a small cohort of South African HIV-infected patients. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 248, 119256.

  1. Photolo, M.M., Sitole, L., Mavumengwana, V., Tlou, M.G. (2021). Genomic and Physiological Investigation of Heavy Metal Resistance from Plant Endophytic Methylobacterium radiotolerans MAMP 4754, Isolated from Combretum erythrophyllum. International Journal of Environmental Research and Public Health,18 (3), 997.

  1. Engelbrecht, Z., Roberts, K.E., Hussan, A., Amenuvor, G., Cronjé, M.J., Darkwa, J., Makhubela, B.C.E., Sitole, L. (2020). Synthesis and anti-cancer activity of bis-amino-phosphine ligand and its ruthenium (II) complexes. Bioorganic & Medicinal Chemistry Letters, 127492.

  1. Photolo, M.M., Mavumengwana, V., Sitole, L., Tlou, M.G. (2020). Antimicrobial and Antioxidant Properties of a Bacterial Endophyte, Methylobacterium radiotolerans MAMP 4754, isolated from Combretum erythrophyllum Seed. International Journal of Microbiology, 9483670.

  1. Sitole, L., Tugizimana, F., Meyer, D. (2019). Multi-platform metabonomics unravel amino acids as markers of HIV/combination antiretroviral therapy-induced oxidative stress. Journal of Pharmaceutical and Biomedical Analysis, 112796.