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Prof Mthokozisi Simelane

Associate Professor
Name: Mthokozisi Simelane
Location: C2 Lab 424 Auckland Park Kingsway Campus
Biochemistry Staff  Staff Members

Contact Details:
Tel: +27 (0) 11 559 3352

Email: msimelane@uj.ac.za

About Prof Mthokozisi Simelane

Prof. Mthokozisi B.C Simelane’s research centers on the exploration and development of plant-derived drugs and herbal medicines. His work spans several key areas, including pharmacognosy, ethnopharmacology, phytochemistry, and natural products chemistry. He specializes in investigating bioactive compounds found in plants, focusing on their potential to treat diseases like malaria, diabetes, and cancer. By integrating traditional knowledge with modern scientific methods, Prof. Simelane’s research contributes to the creation of complementary and alternative medicines, offering innovative solutions for some of the world’s most pressing health challenges.

Links

Google Scholar: https://scholar.google.co.za/citations?user=rWxGs_sAAAAJ&hl=en

ORCiD: http://orcid.org/0000-0002-7798-3020

ResearchGate Profile: https://www.researchgate.net/profile/Mthokozisi-Simelane-2

Recent Publications

  1. Buthelezi, M.N., Tshililo, V.G., Kappo, A.P. et al. Phytochemical evaluation of Ziziphus mucronata and Xysmalobium undulutum towards the discovery and development of anti-malarial drugs. Malar J 23, 141 (2024).
  2. Erhabor OG, Obochi P, Isah MB, Usman MA, Umar IA, Simelane MBC, Shuaibu MN, Islam MS and Ibrahim MA (2024) Possible involvement of sialidase and sialyltransferase activities in a stage-dependent recycling of sialic acid in some organs of type 1 and type 2 diabetic rats. Front. Endocrinol. 15:1289653.
  3. Opoku, F., Govender, P., Shonhai, A. et al. Iso-mukaadial acetate and ursolic acid acetate bind to Plasmodium Falciparum heat shock protein 70: towards targeting parasite protein folding pathway. BMC Chemistry 18, 55 (2024).
  4. Nndwammbi, A.A.T., Dongola, T.H., Shonhai, A. et al. Ursolic acid acetate and iso-mukaadial acetate bind to Plasmodium falciparum Hsp90, abrogating its chaperone function in vitro. Naunyn-Schmiedeberg’s Arch Pharmacol (2024).
  5. Aminu S, Chechet GD, Alkhalil SS, Sobeh M, Daoud R, Simelane MB, Onyike E and Ibrahim MA (2023) Therapeutic efficacy of β-sitosterol treatment on Trypanosoma congolense infection, anemia development, and trans-sialidase (TconTS1) gene expression. Front. Microbiol. 14:1282257. doi: 10.3389/fmicb.2023.1282257
  6. Abdulrashid, N.I.; Aminu, S.; Adamu, R.M.; Tajuddeen, N.; Isah, M.B.; Jatau, I.D.; Aliyu, A.B.; Simelane, M.B.C.; Onyike, E.; Ibrahim, M.A. Phloroglucinol as a Potential Candidate against Trypanosoma congolense Infection: Insights from In Vivo, In Vitro, Molecular Docking and Molecular Dynamic Simulation Analyses. Molecules 2022, 27, 469.
  7. Raphela-Choma, P.P., Simelane, M.B.C. & Choene, M.S. Evaluation of the antiproliferative effect of Iso-mukaadial acetate on breast and ovarian cancer cells. Advances in Traditional Medicine (2022).
  8. Salomane N, Pooe OJ, Simelane MBC (2021). Iso-mukaadial acetate and Ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1. Cell Stress and Chaperones.
  9. Opoku, F.; Govender, P.P.; Pooe, O.J.; Simelane, M.B.C. Evaluating Iso- Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors. Biomolecules 2019, 9, 861.
  10. Msomi NZ, Shode FO, Pooe OJ, Mazibuko-Mbeje S, Simelane MBC (2019). Iso-Mukaadial Acetate from Warburgia salutaris Enhances Glucose Uptake in the L6 Rat Myoblast Cell Line. Biomolecules. Sep 22;9(10).