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Prof Lesetja Motadi

Associate Professor
Name: Lesetja Motadi
Location: C2 Lab 421 Auckland Park Kingsway Campus
Biochemistry Staff  Staff Members

Contact Details:
Tel: +27 (0) 11 559 2404

Email: lmotadi@uj.ac.za

About Prof Lesetja Motadi

Prof Motadi’s cancer genomics and apoptosis including focuses on targeted therapy and immunotherapy in cancer. The research focuses on using cancer patient-derived Ex vivo cells to monitor the response to both therapeutic agents synthesized from natural products. We further look at the biomarkers identified from patient-derived cells as possible therapeutic agents in combination with conventional cancer therapies to reduce the side effects and improve the effectiveness of the therapy.

LINKS

Google scholar : https://scholar.google.com/citations?hl=en&view_op=list_works&gmla=AC6lMd8-POJautekA96BB12sHQv7b6_nl_5Ami2eB3g4S3V7QuPIfLyjFTxKG1XjWFhUFhfl5rbIpUn7KijWoA&user=be8Uf6kAAAAJ

ORCID: https://orcid.org/my-orcid?orcid=0000-0001-6012-6367

Research articles:

  1. ST Lukhele, LR Motadi (2016). Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC complementary and alternative medicine, 2016
  2. LR Motadi, MS Choene, NN Mthembu (2020). Anticancer properties of Tulbaghia violacea regulate the expression of p53-dependent mechanisms in cancer cell lines. Scientific reports, 2020
  3. Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft. Molecular biology reports 50 (5), 4039-4047
  4. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer Management and Research, 3357-3369
  5. George A Asare, Bernice Asiedu, Vivash Naidoo, Josephine Ablakwa, Samuel Adjei, Brodrick Amoah, Richard Obeng-Kyeremeh, Lesetja Motadi, Mokbul Hossain, Munmun Parveen, Antora Akter, Mahmudul Alam, Mohammed Habibur Rahman (2024). The impact of combination therapy of Croton membranaceus and finasteride on benign prostatic hyperplasia (BHP) histo-morphology. Phytomedicine Plus 4 (2), 100543